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. 2017 Apr 10;13(5):561–573. doi: 10.7150/ijbs.19032

Figure 5.

Figure 5

Activation or inhibition of the Wnt/β-Catenin signaling pathway affected expression of miR-370. (A) Wnt3a treatment resulted in decreased expression of miR-370 in U2OS and MG63 cells. The hFOB1.19, U2OS and MG63 cells were treated with 20 ng/ml Wnt3a for 0, 30, 60 and 90 min, then expression of miR-370 was determined by qRT-PCR. (B-D) Treatment with FDI-6 and PKF118-310, but not treatment with 10058-F4, resulted in increased miR-370. The hFOB1.19, MG63 and U2OS cells were treated with FDI-6 (40 μM, B), PKF118-310 (2 μM, C) or 10058-F4 (25 μM, D) for 0, 1, 3 and 6 hr. Next, the expression of miR-370 was determined by qRT-PCR. Representative data from three independent experiments are shown. **P<0.001.