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. 2017 Apr 10;13(5):561–573. doi: 10.7150/ijbs.19032

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Schematic diagram of the FOXM1/β-Catenin complex in human osteosarcoma cells. Elevated DNA methylation in the upstream region of miR-370 results in its down-regulation, which leads to up-regulation of FOXM1 gene. FOXM1 directly binds β-Catenin to form a complex and helps β-Catenin to translocate from the cytoplasm to the nucleus, where the FOXM1-β-Catenin complex interacts with the T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors, up-regulating the expression of downstream target genes of the Wnt/β-Catenin pathway such as c-Myc and Cyclin D1.