Table 2.

Association between FTO SNPs and related diseases

FTO single nucleotide polymorphisms	Date	Study samples	region	Related diseases	Ref.
rs1421085 (T/C)	2013	2,077 T2DM patients and 3,085 healthy people (clinic-based)	European	decreased insulin sensitivity index (P = 0.007) T2DM ( P = 0.001)	[32]
	2013	10447 men and women (population-based)	African American and European	decline in cognitive function, assessed by performance on the Delayed Word Recall Test (P = 0.002)	[33]
rs9939609(T/A)	2011	3,919 T2D patients and 4,172 healthy people (clinic-based)	South Asian	increased chances of T2DM ( P = 10-8)	[34]
	2012	2,858 PCOS patients and 2,358 healthy people (clinic-based)	Asian	T2DM ( P = 6 x 10-8) polycystic ovary syndrome( P = 1.3 x 10-11)	[35]
	2009	37,927 men and women (population-based)	European	increased systolic ( P = 4 x 10-5) increased diastolic blood pressure (P = 0.003) increased chances of hypertension ( P = 2 x 10-4)	[36]
	2012	2,816 patients and 2,932 healthy people (clinic-based)	European and Asian	increased chances of pancreatic cancer	[37]
rs8050136(C/A)	2012	6,835 men and women (population-based)	American Indian	lower eGFR (P = 0.002)	[38]
	2010	21,674 women (population-based)	European	increased risk of cardiovascular disease	[39]
rs8044769	2013	9764 OA patients and 5362 healthy people (clinic-based)	European	increased chances of knee osteoarthritis risk and body mass index	[40]
	2016	196 OA cases and 442 healthy people (clinic-based)	Chinese	not modify individual susceptibility to osteoarthritis (P = 0.791)	[41]
rs11075995 rs9939609 rs17817449(T/G) rs8050136(C/A) rs1477196 rs6499640 rs16953002 rs1121980(T/C)	2015	an overview	African American and European	increased chances of ER-negative breast cancer	[42, 43]
rs16953002	2013	12,313 patients and 55,667 healthy people (clinic-based)	European	Increased chances of melanoma (P = 4 x 10-12)	[44]

abbreviations: e-GFR, estimated glomerular filtration rate; ER, estrogen receptor; T2DM, type 2 diabetes mellitus