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. 2017 May 16;13(5):640–651. doi: 10.7150/ijbs.18636

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Illustrating the therapeutic effect of NGF+bFGF : heparin : PEAD coacervate on DPN-rats and HG-SCs and its mechanism. For the STZ-induced diabetic rats, GFs coacervate mediated nerve regeneration and functional recovery by improved motor and sensory with more ordered nerve fibers and regenerated myelin sheath as well as suppressed apoptosis of SCs. Furthermore, the molecular mechanism of the GFs coacervate protective effect is involved in inhibiting excessive ERS-induced SCs apoptosis.