mRNA expression and activity of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) modulated by black raspberries (BRB) or celecoxib + S,S′-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT). A and C, the mRNA expression of COX-2 and iNOS in rats fed control diet, diet containing celecoxib + PBIT or 5% BRB; B and D, the productions of prostaglandin E2 (PGE2) and nitrite/nitrate in rats fed control diet, diet containing celecoxib + PBIT or 5% BRB. The values are expressed as mean; bars, ± SE; * P < 0.05; ** P < 0.01; *** P < 0.001 versus animals treated with N-nitrosomethylbenzylamine (NMBA) fed control diet.