Figure 2. miR-340-5p enhanced sensitivity of cisplatin (CDDP) in osteosarcoma cells. A, Relative RNA expression of miR-340-5p in MG-63/CDDP and Saos-2/CDDP cells transfected with miR-340-5p or normal control (NC). B, miR-340-5p decreased IC50 of CDDP in MG-63/CDDP and Saos-2/CDDP cells. C, miR-340-5p increased CDDP-induced apoptosis in MG-63/CDDP and Saos-2/CDDP cells. Data are reported as means±SD. **P<0.01 (Student’s t-test). D, miR-340-5p decreased the expression of MRP1 and MDR1 in MG-63/CDDP and Saos-2/CDDP cells exposed to CDDP.
