Table 3.
Intima-media thickness in the descending aorta in relation to alleles (AA, AG, GG; AA, AC, CC) of selected single-nucleotide polymorphisms and valve morphology.
| Genotype |
All AoIMT (mm) |
BAV AoIMT (mm) |
TAV AoIMT (mm) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Allele | ||||||||||
| ANOVA | n | ANOVA | n | ANOVA | n | |||||
| rs488378 | AA | ns | 52 | 1.38 ± 0.30 | ns | 28 | 1.33 ± 0.28 | ns | 24 | 1.42 ± 0.32 |
| AG | 163 | 1.39 ± 0.31 | 93 | 1.33 ± 0.35 | 70 | 1.45 ± 0.25 | ||||
| GG | 122 | 1.36 ± 0.36 | 70 | 1.28 ± 0.32 | 52 | 1.45 ± 0.39 | ||||
| rs200991 | AA | 0.063 | 5 | 1.54 ± 0.27 | ns | 3 | 1.45 ± 0.13 | 0.042‡ | 2 | 1.68 ± 0.44 |
| AC | 89 | 1.31 ± 0.29 | 56 | 1.30 ± 0.32 | 33 | 1.33 ± 0.26 | ||||
| CC | 243 | 1.40 ± 0.34 | 132 | 1.32 ± 0.34 | 111 | 1.48 ± 0.32 | ||||
AoIMT, aortic intima-media thickness; BAV, bicuspid aortic valve; TAV, tricuspid aortic valve; n, number of patients; ANOVA, analysis of variance. Tukey's test for post hoc analysis between groups, ‡CC vs. AC (P = 0.056). For further analysis, we divided the patients into two groups: A allele (AA and AC) vs. non A allele (CC) in the rs200991 locus.