Figure 3.

Allele frequencies for variant alleles in CYP2C9 and inferring *1. Variant allele frequencies for CYP2C9 (NG_008385.1; NC_000010.10; NM_000771.3; Build GRCh37.p13) differ by population as calculated from publicly available data (Fakhro et al. 2016; Lek et al. 2016) leading to varying probability of error in inferring the presence of a *1 allele when only a subset of alleles are reported. Purple shading indicates variant allele frequencies from the variant alleles reported clinically on the cohort. Orange shading indicates variant allele frequencies from actionable alleles not reported on the cohort. Blue shading indicates the frequency of alleles inferred as being *1 in the absence of the variant alleles.