Figure 2.

BcNagZ in complex with MM‐156 and EtBuPUG. (A) The general acid/base histidine‐bearing catalytic loop is highlighted in blue in the BcNagZ: MM‐156 complex, (B) and was disordered in both the EtBuPUG and PUGNAc‐bound complexes (PUGNAc not shown for clarity). The inset surface representations reveal the dramatic change in the NagZ active site due to the catalytic loop displacement caused by the phenylcarbamate extension of EtBuPUG (or PUGNAc). MM‐156 and EtBuPUG are shown as yellow sticks, and nitrogen and oxygen atoms are coloured dark blue and red, respectively.