Fig. 1.

Novel interactors that connect RA and SZ genes: RA genes (gold-colored nodes) and SZ genes (green nodes) connect to each other either directly or through intermediate interactors (red nodes). Novel PPIs predicted with HiPPIP are shown as red lines (“edges”) and known PPIs as blue edges. Their inter-connections mediated by genes that have at least one novel interaction are shown here, whereas all PPIs including those mediated by known interactors are given in Supplementary File 2. Novel interactions that connect RA genes with each other and SZ genes with each other are also shown