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. Author manuscript; available in PMC: 2017 May 23.
Published in final edited form as: Sci Transl Med. 2017 Mar 1;9(379):eaal2408. doi: 10.1126/scitranslmed.aal2408

Fig. 4. Sex-specific miRNA expression and miRNA-based survival prediction.

Fig. 4

(A) Hierarchical clustering plot of miRNAs that showed significant (p<0.05) changes of expression in both paired and unpaired comparisons depending on the outcome and sex of the macaque. No clear pattern of death/survival signature was noted, with females generally dying at a higher dose than males. (B) Sex-specific differences in miR-16-2 expression relative to outcome. Expression of miR-16-2 was lower in males (red) than females (blue), but in both sexes macaques that died showed a downregulation of serum miR-16-2. Lines represent means with standard deviations. (C) Kaplan-Meier curves showing survival relative to miR-16-2 expression. Higher (>median) expression of miR-16-2 was associated with a Hazard Ratio of 0.08 (95%CI 0.01–0.69) of dying during the 60-day post-irradiation period. (D) ROC curve for the miR-30a/miR-126/sex classification model predicting the outcome of irradiation (AUC = 0.80 95%CI 0.60–1.00).