Fig. 4.

Expression of identified genes in brain at different stages of human development. Brainspan RNA-seq developmental transcriptome data showing developmental profiles of PSMD5, AEN, FAM20B, LRRN4, and ID2, the genes found to be similarly methylated in patient-derived iPS cells, ONS cells, and fibroblasts compared to control-derived cells. The x-axis shows the developmental stages (defined by Brainspan, see Methods). The y-axis shows the level of expression in each region at each developmental stage in RPKM (reads per kilobase of exon per million mapped reads)