Table 1.

GO categories of genes differentially methylated between patients and controls (top categories ranked according to p-value)

Category	Functional annotation	p-value	# Molecules
iPS cells
Cellular growth and proliferation	Proliferation of tumor cell lines	0.00835	50
	Proliferation of cells	0.02000	81
Cellular function and maintenance	Autophagy of cells	0.00049	10
	Autophagy	0.00107	13
Carbohydrate metabolism	Synthesis of carbohydrate	0.00402	23
	Quantity of carbohydrate	0.00544	25
Cell cycle	G2 phase of tumor cell lines	0.00144	8
	Arrest in G2 phase of tumor cell lines	0.00202	7
Cell death and survival	Cell death of breast cancer cell lines	0.0109	16
	Apoptosis of breast cancer cell lines	0.0312	13
Cellular movement	Cell movement	0.021	55
ONS cells
Cellular movement	Cell movement	2.41E-16	254
	Migration of cells	7.03E-12	205
Cellular growth and proliferation	Proliferation of cells	1.79E-14	379
	Proliferation of tumor cell lines	7.98E-09	210
Carbohydrate metabolism	Metabolism of carbohydrate	6.88E-13	145
	Quantity of carbohydrate	3.12E-09	104
Cell death and survival	Cell death	4.34E-15	416
	Necrosis	3.27E-13	362
Lipid metabolism	Synthesis of lipid	1.09E-09	144
	Fatty acid metabolism	1.52E-07	112
Fibroblasts
Cellular growth and proliferation	Proliferation of cells	5.03E-10	408
	Proliferation of liver cells	4.59E-04	48
Cellular movement	Cell movement	4.86E-10	264
	Migration of cells	3.54E-07	215
Lipid metabolism	Concentration of lipid	5.93E-09	186
	Synthesis of lipid	5.16E-08	161
Carbohydrate metabolism	Quantity of carbohydrate	8.01E-05	105
	Metabolism of carbohydrate	1.67E-04	134
Cell death and survival	Cell death	1.76E-12	459
	Necrosis	1.62E-09	393