Fig. 1.

Prenatal exposure to POL on GD15 results in changes in the absolute volumes of key brain structures derived using atlas-based segmentation. (a) Prenatal POL treatment did not affect total brain volume, but led to a reduction in the absolute volume (not corrected for total brain volume) of (b) the lateral ventricles by PND180. The absolute volume of (c) the anterior cingulate cortex was also reduced, but there was no effect on (d) corpus striatum volume. Prenatal POL treatment also lead to a reduction in the absolute volumes of (d) the dorsal hippocampus and (e) ventral hippocampus. Data shown are litter means from n = 3 SAL dams and n = 6 POL dams. ^*p < 0.05; ^**p < 0.01; SAL vs. POL using post-hoc Bonferroni correction for multiple comparisons based on a significant age × MIA interaction.