Fig 2. The Kaplan-Meier survival analysis for key outcome variables from starting anti-TNFs/IMs treatment.

(A) Cumulative probabilities of intestinal surgery (the early anti-TNF/IM groups vs. the late therapy group, P < 0.001), (B) Cumulative probabilities of behavioral progression (the early anti-TNF/IM groups vs. the late therapy group, P < 0.001), (C) Cumulative probabilities of developing stricturing complication (the early anti-TNF/IM groups vs. the late therapy group, P = 0.002), and (D) Cumulative probabilities of developing penetrating complication (the early anti-TNF/IM groups vs. the late therapy group, P < 0.001) from starting anti-TNFs/IMs.