Table 5. Cox regression analysis showing hazard ratios (HRs) for variables affecting stricturing complications.
| n (%) | Univariate analysis | Multivariate analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| aHR | 95% CI | P value | aHR | 95% CI | P value | aHR | 95% CI | P value | ||
| Male sex | 386/507 (76.1%) | 0.641 | 0.436–0.943 | 0.024 | 0.649 | 0.438–0.961 | 0.031 | 0.655 | 0.443–0.969 | 0.034 |
| Age at diagnosis, years ≤16 ≥17–40 |
110/507 (21.7%) 397/507 (78.3%) |
reference 1.501 |
0.929–2.426 |
0.097 |
reference 1.583 |
0.976–2.566 |
0.063 |
reference 1.598 |
0.986–2.589 |
0.057 |
| Smoking status Never smoker Ex-smoker Current smoker |
369/507 (72.8%) 30/507 (5.9%) 108/507 (21.3%) |
reference 0.908 1.035 |
0.420–1.963 0.679–1.577 |
0.806 0.874 |
Not retained | Not retained | ||||
| Family history of IBD | 35/507 (6.9%) | 0.993 | 0.485–2.034 | 0.984 | Not retained | Not retained | ||||
| Location at diagnosis Ileum only (L1) Colon only (L2) Ileocolon (L3) |
57/507 (11.2%) 28/507 (5.5%) 422/507 (83.2%) |
reference 0.248 0.707 |
0.073–0.849 0.423–1.181 |
0.026 0.185 |
reference 0.212 0.728 |
0.062–0.729 0.434–1.220 |
0.014 0.228 |
reference 0.212 0.730 |
0.062–0.731 0.436–1.224 |
0.014 0.232 |
| Perianal fistula at diagnosis | 336/507 (66.3%) | 0.843 | 0.585–1.215 | 0.360 | Not retained | Not retained | ||||
| Corticosteroid use <3 months after diagnosis | 297/507 (58.6%) | 1.311 | 0.905–1.901 | 0.152 | Not retained | Not retained | ||||
| Group Early anti-TNF group Early IM group Late therapy group Late therapy group relative to the early anti-TNF/IM groups |
71/507 (14.0%) 269/507 (53.1%) 167/507 (32.9%) |
reference 1.260 2.102 1.732 |
0.643–2.471 1.070–4.131 1.213–2.473 |
0.501 0.031 0.003 |
reference 1.288 2.141 |
0.656–2.531 1.089–4.210 |
0.462 0.027 |
1.736 |
1.209–2.493 |
0.003 |
HR, hazard ratio; CI, confidence interval; IM, immunomodulator; IBD, inflammatory bowel disease.