Table 2. Inhibitory activities of oligopeptides against full-length NDM-1.
Oligopeptides | Amino acid sequences a | IC50 (μM) (Mean±SD) |
---|---|---|
Di-peptide | ||
1 | Cys-His | 182±14 |
2 | Cys-Phe | 113±9 |
3 | Cys-Tyr | >300 |
4 | Cys-Val | 235±18 |
5 | Cys-Asp | 68±5 |
Tri-peptide | ||
6 | Cys-Gly-His | 263±21 |
7 | Cys-Gly-Phe | 144±13 |
8 | Cys-Gly-Tyr | >300 |
9 | Cys-Gly-Val | 249±21 |
10 | Cys-Gly-Asp | >300 |
a All the residues in oligopeptides are natural amino acids (L-amino acid).