Table 4.

HRs for clinical events among warfarin users and enriched subjects

Outcomes	Univariate (HR, 95% CI)	P-value	Multivariablea (aHR, 95% CI)	P-value	Propensity scoreb (aHR, 95% CI)	P-value
Warfarin users vs nonusers
Hemorrhage	1.92 (0.83, 4.42)	0.13	1.56 (0.64, 3.80)	0.33	1.50 (0.60, 3.76)	0.39
Stroke or MI	1.64 (0.98, 2.75)	0.06	1.38 (0.80, 2.39)	0.25	1.12 (0.64, 1.98)	0.69
Overall eventc	1.71 (1.10, 2.66)	0.02	1.43 (0.89, 2.28)	0.13	1.22 (0.75, 1.97)	0.42
Enriched vs nonenriched subjects
Hemorrhage	2.65 (1.18, 5.99)	0.02	2.23 (0.84, 5.95)	0.11	2.25 (0.94, 5.41)	0.06
Stroke or MI	2.20 (1.33, 3.64)	0.002	2.13 (1.16, 3.94)	0.02	1.67 (0.97, 2.87)	0.06
Overall eventc	2.32 (1.51, 3.56)	<0.0001	2.16 (1.29, 3.63)	0.004	1.81 (1.15, 2.88)	0.01

Notes:

^aThe HRs were adjusted for albumin (continuous) and CHADS₂ (tertiles). These variables were found to effect the univariate estimate by >10% and were included in the multivariable adjustment.

^bThe HRs were estimated with propensity score adjustment. The following comorbidities were included in the propensity score model: age, sex, body mass index (continuous), fasting plasma glucose, albumin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol, and CHADS₂ (tertiles).

^cOverall event includes a combination of the following clinical events: hemorrhage, stroke, and myocardial infarction.

Abbreviations: CI, confidence intervals; aHR, adjusted hazard ratio; HR, hazard ratio; MI, myocardial infarction.