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Sequence alignment of PDZ3 in USH1C isoforms a and b. The secondary structure elements are shown according to the USH1C structure reported in this study. Identical and highly similar residues are colored (yellow for hydrophobic residues, blue for positively charged residues, red for negatively charged residues, and green for other polar residues). The C-terminal-TFF critical for binding to Myo7b CMF are highlighted with a magenta box.
