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Generation of Crkl exon2Δ/exon2Δ embryos. (A) A multigenerational cross was used to generate Crkl exon2Δ/exon2Δ embryos. (B) Deletion was validated by Sanger sequencing of cDNA indicating splicing of exon 1 to exon 3 (red arrow). (C) Exon 2-deleted protein sequence showing premature stop, and Inset chart comparing predominant phenotypes of Crkl−/− to Crkl exon2Δ/exon2Δ.
