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. 2017 Apr 24;114(19):4981–4986. doi: 10.1073/pnas.1619523114

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Fig. 7. — Crkl+/exon2Δ males exhibit cryptorchidism, smaller testes, fewer sperm, and subfertility compared with Crkl^+/+ controls. Eighteen- to 20-wk-old males (n = 11 per group) were analyzed for cryptorchidism (A) (testicles circled in red; bladder in green, penis indicated by white star), testicular size (B) (Inset: Left wild-type, Right Crkl+/exon2Δ). H&E staining of testes (C) confirmed abnormal testicular histology in approximately half of the Crkl+/exon2Δ seminiferous tubules with atresia and vacuolization of tubules apparent (*). (Magnification, 10×.) Distribution of cryptorchidism was graphed (D). Testicle weight was graphed as a proportion of body weight (E). Genotype-blinded sperm count was assessed by hemacytometry (F). n = 11 cages per group were mated at 11 wk of age and assessed for fertility across three litters (G). Error bars represent SEM.