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Average pups per litter is decreased in Crkl heterozygote mutants of both sexes. n ≥ 50 litters per group (5 consecutive litters with n ≥ 11 cages per group) were analyzed for pup number. Heterozygote mutants of both sexes exhibit subfertility. Male subfertility was further assessed; female subfertility is the subject of future studies.
