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Soma degeneration is coupled to axon degeneration in glaucoma in D2.C3−/− mice. (A) Representative images of Nissl staining in flat-mounted retinas in eyes with NOE axon damage and severe (SEV) axon damage. No differences in morphology or cell count were observed based on C3 genotype. (B) SEV eyes have significantly fewer cells in the RGC layer compared with NOE eyes (P < 0.05).
