Table S1.

Information on GRN mutation carriers and healthy controls

	GRN mutation carriers						MRI Imaging
	Total	Symptomatic	Presymptomatic	Controls	Carriers vs. controls	P*	Symptomatic GRN carriers	Controls	Carriers vs. controls	P*
No. of patients	35	23	12	25			20	42
No. with OCD behaviors	20	16	4	0		<0.001	12	N/A
Age†	58.8 ± 10.8	62.2 ± 8.3†	52.3 ± 12.6†	58.8 ± 5.2	t = 0.01, df = 58	0.99	61.3 ± 7.5	61.0 ± 7.2	t = 0.16, df = 60	0.87
Education, y	16.5 ± 3.4	16.6 ± 3.7	16.2 ± 3.0		t = 1.00, df = 48	0.32	N/A	N/A
Sex (M:F)	12:21	10:13	4:8	11:14	χ2 = 0.10, df = 1	0.76	10:10	24:18	χ2 = 0.28, df = 1	0.60
Hand (R:L:A)	N/A	N/A	N/A	N/A	N/A		19:1	40:2	χ2 = 0.28, df = 1	0.97
Scanner Siemens 3T: Siemens 1.5T	N/A	N/A	N/A	N/A	N/A		13:7	30:12	χ2 = 0.26, df = 1	0.61

^*Fisher’s exact test.

^†Values for age are mean ± SD. The age in patients with obsessive–compulsive behaviors is the age when the behaviors were first noted. The age of symptomatic carriers without obsessive–compulsive behaviors is the age at the first evaluation. The age of carriers without symptoms or obsessive–compulsive behaviors is the age at the most recent assessment. A, ambidextrous; F, female; L, left-handed; M, male; R, right-handed; T, Tesla.