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Signaling through CXCR4 induces the Erk and Akt pathway in an IgD-dependent manner. Quantification of Western blot analysis of WT (gray), IgM−/− (blue), and IgD−/− (red) splenic B cells after stimulation with either 100 ng/mL CXCL12 or 1 µM Lat-A for 5 min compared with resting cells. Data represent mean ± SD of four independent experiments.
