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Modification of distal and proximal cis unsaturations of cis,cis-diunsaturated meroacid precursors in the pathway to synthesis of oxygenated meroacids. MmaA4 converts the distal cis unsaturation to a secondary alcohol with an adjacent methyl branch. MmaA1 converts the proximal cis unsaturation to an allylic methyl branch with trans unsaturation. SAM is the cofactor in these reactions. t and c, trans and cis isomers, respectively.
