FIG. 9.

Sequence alignment of the proposed M. tuberculosis β-hydroxy-acyl-ACP dehydrase FabZ (Rv0098) with E. coli CFT073 FabZ (AAN78709), S. pneumoniae FabZ (NC_003028, SP0424 open reading frame), and E. coli CFT073 FabA (AAN79558). Multiple-sequence alignments were obtained with the Clustal W program (version 1.8) (106). Active-site residues His and Glu are indicated by asterisks. Black shading indicates identical residues; gray shading indicates similar residues. Hyphens represent gaps introduced to maintain the alignment. For better visualization, the first 23 residues of E. coli FabA are not included in the alignment, because none of them matched in the comparison.