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. 2017 May 1;114(20):5247–5252. doi: 10.1073/pnas.1702725114

Fig. 4.

Fig. 4.

Genes encoding μ-opioid and κ-opioid, but not δ-opioid, receptors display above-average expression in OT-enriched regions. (A) Microarray expression of OXT and OXTR from 190 regions averaged across six postmortem human brains from the Allen Human Brain Atlas (AHBA). Ten tissue samples displayed OXT expression 1 SD above the mean: LHT, PVH, SO, dorsomedial hypothalamic nucleus (DMH), lateral hypothalamic area, anterior region (LHA), lateral hypothalamic area, medial region (LHM), ventral hypothalamic area, medial region (VHM), perifornical nucleus (PeF), posterior hypothalamic area (PHA), and preoptic region (PrOR). (B) μ-Opioid and κ-opioid receptor genes are expressed significantly more than δ-opioid receptor genes across the top three OXT-enriched regions (data from the remaining seven OXT-enriched regions are shown in Fig. S7). Each line connects samples from the same donor. Different numbers of lines are due to nonuniform sampling across the six AHBA donors. The horizontal ticks indicate the mean of different donors. (C) Across all 190 regions, μ-opioid and κ-opioid receptors displayed above-average expression within the eight OXT-enriched samples. *P < 0.05, **P < 0.01, ***P < 0.001.