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. 2017 May 1;114(20):5237–5242. doi: 10.1073/pnas.1703476114

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Fig. 5. — CDK1-mediated EZH2 phosphorylation resulted in an abnormal H3K27me3 profile. (A) Lysates from BM cells of mice were analyzed with Western blot by using the indicated antibodies. (B) Lysates from OA3 cells transfected with siRNA against DNMT3A were analyzed with Western blot. (C) The number of peaks of H3K27me3 in leukemic cells compared with WT samples. (D) KEGG enrichment analysis of genes with loss of enrichment of H3K27me3 in leukemic mice. (E and F) ChIP-seq profiles of H3K27me3 at the Hoxa family genes and mTOR.