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(A) Number of methylation peaks was compared between Dnmt3aWT/WT and Dnmt3aR878H/WT mice. Mean ± SEM values are shown. (B) MeDIP-seq analysis of the mTOR gene showed a local hypomethylation pattern in the gene body, whereas the promoter region exhibited no changes of methylation status in mice transduced with R882H DNMT3A compared with mice transduced with WT DNMT3A.
