. Author manuscript; available in PMC: 2018 Apr 1.

Published in final edited form as: J Biomed Inform. 2017 Mar 8;68:150–166. doi: 10.1016/j.jbi.2017.03.003

Table 2.

Example searches for concepts in a 32,000-dimensional binary PSI space derived from version 25.1 of the SemMedDB database, containing 82,239,652 extracted predications. The “Results” column shows the nearest neighboring concept vectors to the “Cue” vector. The score is the number of standard deviations above the mean of ( $1 - \frac{2 \times hamming distance}{dimensionality}$ ) for all vectors in the search vector store. ASSOC=ASSOCIATED_WITH. INV indicates the inverse of a predicate - if “subject PRED object” then “object PRED-INV subject”.

Cue	Target	Results	Comments
S(haloperidol)	Semantic vectors	93.37:haloperidol 30.43:clozapine 26.91:risperidone 26.74:antipsychotic_agents 25.92:sulpiride	Other antipsychotic agents (and this drug class).
S(haloperidol) ⊘ P(TREATS)	Context vectors	8.61:delirium 8.35:schizophrenia 7.72:chronic_schizophrenia 7.63:mania acute 7.37:agitation	Therapeutic applications of haloperidol.
S(haloperidol) ⊘ P(CAUSES)	Context vectors	11.46:catalepsy 7.66:akinesia 6.37:adverse_effects 6.00:hyperactive_behavior 5.50:vomiting	Side effects of haloperidol.
S(haloperidol) ⊘ P(TREATS) ⊗ (ASSOC)	Semantic vectors	8.39:syt4 8.38:calb2 8.38:gulp1 8.38:mir138-2 8.38:mir137hg	Genes associated with conditions treated by haloperidol.