Table 1.

Models and parameters used in the fitting of ASH responses with time-differential equations.

DOI: http://dx.doi.org/10.7554/eLife.21629.017

Conditions	ASH, wild-type			ASH, odr-3(n2150)	ASH, odr-3(n1605)	ASH, wild-type slow component
Durations of up/down phase	Up 45 s	Up 90 s	Up 180 s	Up 90 s	Up 90 s	Up 90 s
Model	$X\left(t\right)=kI$	$X\left(t\right)=kI$	$X\left(t\right)=kI$	$X\left(t\right)=kI$	$X\left(t\right)=kI$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$
	$I=\frac{dC\left(t\right)}{dt}$	$I=\frac{dC\left(t\right)}{dt}$	$I=\frac{dC\left(t\right)}{dt}$	$I=\frac{dC\left(t\right)}{dt}$	$I=\frac{dC\left(t\right)}{dt}$	$I=\frac{dC\left(t\right)}{dt}$
Parameters used for fitting to ΔF/F0
k	56.1 [μM−1·s]	80.9 [μM−1·s]	121.9 [μM−1·s]	49.1 [μM−1·s]	46.7 [μM−1·s]	2.96 [μM−1]
τ	-	-	-	-	-	10.4 [s]
Parameters used for fitting to estimated calcium concentration
k	3.9 [s]	6.2 [s]	7.9 [s]	2.8 [s]	2.9 [s]	-
τ	-	-	-	-	-	-
fmax	9.4	9.5	9.2	9.1	8.7	-
fmin	0.79	0.79	0.77	0.76	0.73	-
Xbase	103.8 [nM]	92.2 [nM]	107.0 [nM]	108.2 [nM]	109.7 [nM]	-