Table 2.

Models and parameters used in the fitting of AWB responses with leaky integrator equations.

DOI: http://dx.doi.org/10.7554/eLife.21629.018

Conditions	AWB, wild-type			AWB, unc-13(e51)	AWB, unc-31(e928)	AWB, odr-3(n2150)	AWB, odr-3(n1605)
Durations of up/down phase	Down 45 s	Down 90 s	Down 180 s	Down 90 s	Down 90 s	Down 90 s	Down 90 s
Model	${\displaystyle \frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)}$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$	$\frac{dX\left(t\right)}{dt}=kI-\frac{1}{\tau }X\left(t\right)$
	$I=-\frac{dC\left(t\right)}{dt}$	$I=-\frac{dC\left(t\right)}{dt}$	$I=-\frac{dC\left(t\right)}{dt}$	$I=-\frac{dC\left(t\right)}{dt}$	$I=-\frac{dC\left(t\right)}{dt}$	$I=-\frac{C\left(t\right)-C(t-\Delta t)}{\Delta t}$	$I=-\frac{C\left(t\right)-C(t-\Delta t)}{\Delta t}$
						(∆t = 67 s)	(∆t = 66 s)
Parameters used for fitting to ΔF/F0
k	4.6 [μM−1]	3.6 [μM−1]	3.0 [μM−1]	2.6 [μM−1]	4.9 [μM−1]	8.7 [μM−1]	7.7 [μM−1]
τ	19.7 [s]	28.1 [s]	25.0 [s]	34.5 [s]	28.1 [s]	25.2 [s]	23.5 [s]
Parameters used for fitting to estimated calcium concentration
k	0.40	0.37	0.33	0.26	0.44	1.00	0.87
τ	21.1 [s]	28.5 [s]	25.0 [s]	37.3 [s]	30.7 [s]	17.7 [s]	17.7 [s]
fmax	9.7	10.1	8.5	9.6	8.9	10.9	10.4
fmin	0.81	0.84	0.71	0.80	0.74	0.91	0.87
Xbase	66.1 [nM]	56.7 [nM]	89.6 [nM]	66.7 [nM]	81.2 [nM]	41.8 [nM]	51.5 [nM]