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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Invest Dermatol. 2017 Jan 20;137(6):1277–1285. doi: 10.1016/j.jid.2017.01.007

Figure 2. Cutaneous and Serum Cytokines Increase in Aged Mice.

Figure 2

Both flanks of 12-month old C57BL/6J mice were used in this study. The dermis and epidermis were separated by heat (Feingold et al., 1991). Fig 2a: Expression levels of cytokine mRNA in the skin; Fig 2b: Serum cytokine levels; Fig 2c: Serum amyloid A levels in 7-week old vs. 12-month old mice. Fig 2d: mRNA levels for amyloid A and TNFα in the liver (red dots) and the epidermis (black dots) of 12-month old mice. Data were normalized to normal young controls, setting normal young controls as 100% (dotted lines). A Mann Whitney two-tailed test was used to determine the significances between aged and young mice. P values were vs. the non-tape stripped normal controls.