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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Cytokine. 2017 Feb 24;95:55–63. doi: 10.1016/j.cyto.2017.02.008

Figure 1. IL-37tg old mice and WT old mice treated with recombinant IL-37 are resistant to endotoxemic cardiac depression.

Figure 1

WT and IL-37tg old mice were treated with lipopolysaccharide (LPS, 0.5 mg/kg, iv) or normal saline. A group of WT old mice were treated with LPS and then with recombinant IL-37 (rIL-37, 0.05 mg/kg, iv) 30 minutes later. Representative pressure-volume loops show that WT old mice had reduced left ventricle (LV) function at 6 hours after treatment with LPS alone. Expression of IL-37 (IL-37tg) or administration of rIL-37 improved LV function in old mice exposed to LPS.