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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Cytokine. 2017 Feb 24;95:55–63. doi: 10.1016/j.cyto.2017.02.008

Figure 4. IL-37tg old mice produce lower levels of cardiodepressant cytokines during endotoxemia.

Figure 4

IL-37tg and WT old mice were treated with lipopolysaccharide (LPS, 0.5 mg/kg, iv) or normal saline. Levels of IL-1β, TNF-α, and IL-6 in the myocardium and plasma were analyzed by ELISA 6 hours after LPS treatment. Levels of IL-1β (A), TNF-α (B), and IL-6 (C) in the myocardium and plasma were lower in IL-37tg mice. Data is expressed as mean ± SD. n=6 mice in each group; one-tailed ANOVA; *P<0.05 vs. corresponding control (Ctrl); #P<0.05 vs. WT mice treated with LPS.