Table 2.
Fractional anisotropy (FA) and mean diffusivity (MD) values across the study groups in the whole brain and by region (N=135)
| HIV-negative | HIV-positive | ANOVA F-values | |||||
|---|---|---|---|---|---|---|---|
| Coc−(N=35) | Coc+(N=37) | Coc−(N=37) | Coc+(N=26) | Main effect HIV | Main effect Cocaine | Interaction effect | |
| FA values | |||||||
| Whole brain | 0.482(0.003) | 0.484(0.003) | 0.475(0.003) | 0.473(0.003) | 8.670** | 0.007 | 0.349 |
| Body of corpus callosum | 0.736(0.005) | 0.741(0.005) | 0.726(0.005) | 0.729(0.006) | 4.798* | 0.481 | 0.051 |
| Genu of corpus callosum | 0.757(0.005) | 0.766(0.005) | 0.747(0.005) | 0.750(0.006) | 6.539* | 1.269 | 0.425 |
| Splenium of corpus callosum | 0.848(0.004) | 0.851(0.004) | 0.842(0.004) | 0.838(0.004) | 6.339* | 0.069 | 0.712 |
| Caudate | 0.505(0.004) | 0.504(0.003) | 0.499(0.003) | 0.498(0.004) | 2.505 | 0.048 | 0.010 |
| Cerebellum | 0.417(0.002) | 0.417(0.002) | 0.412(0.002) | 0.411(0.003) | 4.938* | 0.081 | 0.003 |
| Frontal lobe | 0.459(0.003) | 0.460(0.003) | 0.451(0.003) | 0.451(0.004) | 7.081** | 0.055 | 0.036 |
| Insula | 0.423(0.003) | 0.424(0.003) | 0.415(0.003) | 0.414(0.004) | 8.094** | 0.043 | 0.139 |
| Occipital | 0.424(0.003) | 0.426(0.003) | 0.418(0.003) | 0.412(0.004) | 9.261** | 0.216 | 1.620 |
| Parietal | 0.485(0.003) | 0.489(0.003) | 0.481(0.003) | 0.478(0.004) | 5.413* | 0.046 | 0.958 |
| Putamen | 0.492(0.003) | 0.491(0.003) | 0.487(0.003) | 0.486(0.004) | 2.358 | 0.037 | 0.000 |
| Temporal | 0.421(0.003) | 0.423(0.003) | 0.415(0.003) | 0.410(0.003) | 8.955** | 0.134 | 1.565 |
| Thalamus | 0.490(0.003) | 0.492(0.003) | 0.483(0.003) | 0.484(0.003) | 6.493* | 0.190 | 0.027 |
| MD values (10−3 mm2/s) | |||||||
| Whole brain | 0.793(0.004) | 0.792(0.004) | 0.799(0.004) | 0.805(0.005) | 4.621* | 0.248 | 0.492 |
| Body of corpus callosum | 0.849(0.006) | 0.844(0.006) | 0.863(0.006) | 0.861(0.007) | 6.443* | 0.335 | 0.046 |
| Genu of corpus callosum | 0.824(0.006) | 0.818(0.006) | 0.840(0.006) | 0.833(0.007) | 5.850* | 0.955 | 0.000 |
| Splenium of corpus callosum | 0.726(0.006) | 0.729(0.005) | 0.737(0.005) | 0.732(0.006) | 1.404 | 0.000 | 0.507 |
| Caudate | 0.807(0.005) | 0.810(0.005) | 0.814(0.005) | 0.816(0.006) | 1.365 | 0.170 | 0.000 |
| Cerebellum | 0.703(0.005) | 0.709(0.004) | 0.712(0.004) | 0.712(0.005) | 1.906 | 0.315 | 0.403 |
| Frontal lobe | 0.800(0.005) | 0.798(0.005) | 0.804(0.005) | 0.809(0.006) | 2.628 | 0.120 | 0.570 |
| Insula | 0.824(0.005) | 0.822(0.005) | 0.832(0.005) | 0.832(0.006) | 3.574 | 0.060 | 0.042 |
| Occipital | 0.762(0.005) | 0.760(0.005) | 0.761(0.005) | 0.778(0.005) | 3.251 | 2.027 | 3.638 |
| Parietal | 0.772(0.005) | 0.771(0.005) | 0.774(0.005) | 0.782(0.005) | 2.027 | 0.354 | 0.958 |
| Putamen | 0.796(0.005) | 0.799(0.005) | 0.804(0.005) | 0.803(0.006) | 1.605 | 0.000 | 0.120 |
| Temporal | 0.819(0.005) | 0.816(0.005) | 0.825(0.005) | 0.828(0.006) | 3.112 | 0.000 | 0.456 |
| Thalamus | 0.839(0.008) | 0.841(0.008) | 0.858(0.008) | 0.862(0.009) | 6.692* | 0.151 | 0.036 |
*
p < .05
**
p < .01
All models controlled for age, gender, education, and protocol. Estimated marginal means and standard error values are presented.