Table 1.

Clinical and laboratory (CSF and blood) characteristics

Sample	0	1	A**	B	C	D
Clinical Parameters
Days after ARV change	AIDS diagnostic	−42	0	76	545	940
CPE	6	6	9	9	9	9
FIM motor		34	14	53	70
FIM cognitive		17	8	29	32
FIM total		51	22	82	102
IHDS			0*	9.5	12	10
GDS			ND*	2.85	2.05	1.06
CSF***
HIV RNA copies/mL			23821	<50	<50	<50
WBC cells/mm3	0.3	26	20	2.5	2.2	2.8
Linphocytes %		92	99			-
Glucosis mg/dL	48	35	38	53	55	57
GL CSF/serum	0.58	0.29	0.48		0.67	0.65
TP mg/dL	33	268	339	75	42	30
LA mmol/L	2.2	3.1	2.8	2.6	1.7	1.7
Albumin mg/L			1770	173	310	157
Q. Alb			91.7	5.3	8.7	5.1
Alb leakage mg/day			843	77	15	12
IgG mg/L			1380	237	334	90.3
Q. IgG			95.2	19	22.4	8.6
IgG syntheses mg/day			398	99	133	29
Blood
Platelets 103μL	94	136	186		205	216
CD4 cells/mm3	6	838	239		382	348
CD8 cells/mm3	85	3991	967		882	624
CD4/CD8	0.07	0.21	0.25		0.43	0.56
HIV RNA copies/mL		69	851	<50	<50	<50

CSF Sample 0 (date of lumbar puncture 28/09/08); sample 1 (lumbar puncture 13/01/11)

CPE- CNS Penetration Effectiveness Score (Letendre et al. 2010); IHDS- International HIV Dementia Scale (Sacktor et al. 2005); GDS- global deficit score; GL- glucosis; TP- total protein; LA- lactic acid; Alb- albumin

^*Glasgow Coma scale 7 (2+1+4);

^**change ARV scheme to (zidovudine (AZT), efavirenz (EFZ), Lamivudina (3TC); CPE 4+2+3=9)

^***Etiological agent search in all CSF samples by standard microbiological tests: bacteria (gram smear and culture negative); fungus (direct CSF smear, culture and latex to C. neoformans capsular antigen, negative); Mycobacterium tuberculosis (Ziehl smear, culture, PCR negative); virus (PCR for HSV, enterovírus, VZV, CMV, HHV6, HHV7, EBV and JC negative).

Functional Independence Measure (FIM): reference scores- total score 126; motor 91; cognitive 35.

HIV RNA levels in blood and CSF were measured by branched DNA assay (Siemens) with a nominal limit of detection of 50copies/mL. CD4 counts were quantified by flow cytometry (FACSCalibur-Multitest).