Table 4.

Neuronal injury, monocyte and macrophage activation biomarkers on cerebrospinal fluid and serum

CSF							SERUM
Protein	unity	A	B	C	D	CTRL*	A	B	C	D	CTRL*
Neuronal Injury Biomarkers
T Tau	pg/mL	2723.64	234.2	771.55	137.7	633.7 (531.2; 764.6)
P Tau 181	pg/mL	59.39	200	59.39	162	132.0 (106.5; 179.5)
Aβ-38	pg/mL	899.91	1437.11	1581.10	355.76	2209 (1840; 2509)	9.39	48.60	2.48	7.82	7.226 (2.480; 22.50)
Aβ-40	pg/mL	2390.24	2773.68	3364.22	688.51	4561 (4182; 5116)	99.70	194.30	18.47	114.30	117.9 (108.0; 141.7)
Aβ-42	pg/mL	240.80	221.54	400.92	52.01	618.3 (548.6; 735.0)	8.60	6.66	1.69	7.60	7.98 (5.24; 9.55)
Aβ Total	pg/mL	3530.95	4432.32	5346.23	1096.29	7357 (6665; 8316)	117.65	249.56	22.64	129.74	140.6 (121.7; 172.6)
sAPPα	ng/mL	4.04				27.80 (16.40; 35.15)	20.59				23.21 (17.99; 30.67)
sAPPβ	ng/mL	3.27				35.75 (27.05; 43.35)	1.34				2.569(1.782; 4.716)
sAPPα/β		1.24				0,7557 (0,6007; 0,8710)	15.38				8.68(4.7 8;13.26)
NFL	pg/mL	33121.95	15957.32	2351.68	702.52	659.6 (538.8; 801.6)
MBP**	ng/mL	10.9	2.98	1.43	0.65	< 1.1
Ferritin ***	ng/mL	29.6	7.21	2.82	2.07	5 (3;7)	649.64	211.41	132.83	117.50	12–300
Monocyte and macrophage activation biomarkers
sCD14	pg/mL	1139105	219330.9	90751.61	47545.63	85250 (69540; 100000)	1896669	1832895	1909590	933747	1.4370e+006 (1.3550e+006; 1.5490e+006)
Neopterin	nmol/L	188.94	39.82	8.66	7.14	4.985 (4.618;5.641)
β2M****	mg/L	15.5	2.07	6.57	1.38	1.3±0.5	3.77	2,22	2,57	2,19	0.9–3.0

^*median (IQR);

^**myelin basic protein (MBP) normal range (Greene et al, 2012);

^***Ferritin normal range (Petzold et al, 2002);

^****β ₂M normal range (Caudie et al, 2005)