Table 4.

Cox proportional hazards—main effects for anxiety. Outcome: MCI

Predictor variables	Main effects (unadjusted) hazard ratio (95% CI)	Main effects adjusteda hazard ratio (95% CI)	Main effects adjustedb w/ε4 carrier status hazard ratio (95% CI)	Main effects adjustedc AD medication use hazard ratio (95% CI)
Anxiety	2.13 (1.85–2.44)**	2.08 (1.81–2.39)**	1.98 (1.70–2.31)**	1.98 (1.70–2.31)**
Use of an anxiolytic	2.07 (1.45–2.94)**	1.95 (1.37–2.79)**	2.09 (1.42–3.07)**	1.89 (1.27–2.80)**
Did not use anxiolytic	2.17 (1.87–2.52)**	2.13 (1.83–2.48)**	2.00 (1.69–2.37)**	1.91 (1.61–2.26)**
- Alprazolam	.999 (.374–2.67)	1.06 (.391–2.89)	1.28 (.445–3.66)	1.22 (.420–3.55)
- No Alprazolam use	2.17 (1.89–2.49)**	2.12 (1.84–2.44)**	2.01 (1.72–2.35)**	1.99 (1.71–2.33)**
- Clonazapam use	2.59 (1.08–6.19)*	2.62 (1.04–6.60)*	3.45 (1.29–9.12)*	2.96 (1.03–8.51)*
- No Clonazapam use	2.12 (1.85–2.44)**	2.07 (1.80–2.38)**	1.96 (1.67–2.29)**	1.95 (1.66–2.28)**
- Lorazapam use	2.85 (1.43–5.67)*	2.93 (1.45–5.93)*	2.35 (1.06–5.19)*	2.28 (1.03–5.05)*
- No Lorazapam use	1.86 (1.69–2.05)**	2.04 (1.77–2.35)**	1.97 (1.68–2.31)**	1.95 (1.67–2.29)**
- Paroxetine use	1.54 (.519–4.58)	1.59 (.507–4.97)	1.84 (.545–6.21)	1.77 (.515–6.06)
- No Paroxetine use	2.15 (1.87–2.46)**	2.10 (1.82–2.41)**	2.00 (1.71–2.33)**	1.98 (1.69–2.32)**
- Venlafaxine use	.860 (.246–3.01)	.305 (.063–1.48)	.191 (.022–1.66)	.179 (.019–1.65)
- No Venlafaxine use	2.17 (1.89–2.49)**	2.13 (1.85–2.44)**	2.04 (1.75–2.38)**	2.03 (1.74–2.37)**

^aAdjusted for sex, age, education, race, and Hispanic origin.

^bAdjusted for sex, age, education, race, Hispanic origin, and E4 carrier status

^cAdjusted for sex, age, education, race, Hispanic origin, and AD medication use.

^*Indicates statistical significance at p <.05.

^**Indicates p <0.001.