Table 6.

Cox proportional hazards—additive effects for anxiety × ε4 carrier status. Outcome: MCI

Predictor variables	Main effects (unadjusted) hazard ratio (95% CI)	Main effects adjusteda hazard ratio (95% CI)	Main effects adjustedb hazard ratio (95% CI)
Anxiety × ε4 carrier	2.37 (1.84–3.04)**	2.68 (2.09–3.44)**	2.67 (2.08–3.44)**
Use of an anxiolytic	3.16 (1.86–5.37)**	3.26 (1.92–5.56)**	2.72 (1.57–4.71)**
Did not use anxiolytic	2.20 (1.66–2.93)**	2.54 (1.91–3.39)**	2.35 (1.76–3.15)**
- Alprazolam	2.44 (.215–27.68)	4.34 (.335–56.34)	2.41 (.675–8.61)
- No Alprazolam use	7.20 (5.09–10.19)**	8.76 (6.16–12.46)**	2.61 (2.02–3.38)**
- Clonazapam use	7.41 (2.39–22.95)**	8.42 (2.48–28.64)**	6.51 (1.54–27.49)*
- No Clonazapam use	2.25 (1.73–2.91)**	2.54 (1.96–3.29)**	2.52 (1.94–3.26)**
- Lorazapam use	2.78 (.900–8.61)	2.88 (.860–9.65)	2.79 (.830–9.39)
- No Lorazapam use	2.33 *(1.81–3.02)**	2.64 (2.04–3.41)**	2.60 (2.01–3.37)**
- Paroxetine use	2.01 (.256–15.85)	3.50 (.353–34.76)	3.23 (.312–33.50)
- No Paroxetine use	2.38 (1.85–3.06)	2.70 (2.10–3.47)**	2.67 (2.07–3.43)**
- Venlafaxine use	.878 (.111–6.93)	.324 (.032–3.25)	.196 (.019–2.05)
- No Venlafaxine use	2.41 (1.87–309)**	2.73 (2.12–3.51)**	2.70 (2.10–3.48)**

^aAdjusted for sex, age, education, race, and Hispanic origin.

^bAdjusted for sex, age, education, race, Hispanic origin, and AD medication use.

^*Indicates statistical significance at p <.05.

^**Indicates p <0.001.