Table 3.

Significant SNPs (P_meta< 5 × 10⁻⁸) from the genome-wide meta-analysis on the sense of smell in African-Americans (AAs) and European-Americans (EAs)

Race	SNP	Chr	Gene	BP	Effect Allele	Other Allele	rsq a	MAF	Effect size b	s.e.	P_meta	I2 for hetero	P for Cochran’s Q	FDR
AA	rs139300691	9q31.2	KLF4-ACTL7B	110587938	A	G	0.80	0.02	−0.30	0.05	1.69×10−9	41.60	0.19	0.015
	rs72679931	4q32.2	RAPGEF2-FSTL5	162245253	A	T	0.62	0.01	−0.35	0.06	3.73×10−9	63.10	0.04	0.013
	rs115661734	18q21.2	TCF4-LOC100505474	53597122	T	G	0.95	0.01	−0.29	0.05	4.67×10−9	70.10	0.07	0.013
	rs187695731	4q28.3	NONE-PCDH10	132608408	T	C	0.74	0.02	0.29	0.05	7.02×10−9	0.00	0.49	0.015
	rs148809765	1P36.33	KIAA1751	1890756	T	C	0.49	0.01	−0.35	0.06	1.24×10−8	83.70	0.01	0.015
	rs16951602	18q21.1	MYO5B	47680617	A	G	0.75	0.03	0.21	0.04	1.35×10−8	0.00	0.70	0.015
	rs116393901	1p13.1	MIR320B1-CD2	117241009	A	G	0.90	0.01	0.28	0.05	3.25×10−8	63.40	0.10	0.015
	rs75904654	1q32.1	NR5A2-LINC00862	200272654	A	T	0.46	0.01	0.36	0.07	3.39×10−8	31.00	0.23	0.015
	rs112989064	16q12.1	SALL1-C16orf97	51631845	T	C	0.68	0.02	−0.28	0.05	4.21×10−8	0.00	0.91	0.015
EA	rs78633367	15q14	RASGRP1	38816290	T	C	0.56	0.02	0.16	0.03	4.14×10−9	61.80	0.11	0.002
	rs145898638	10q21.3	REEP3-ANXA2P3	66491421	T	G	0.70	0.01	−0.18	0.03	4.04×10−8	0.00	0.85	0.006

Chr.: Chromosome. MAF: minor allele frequency. s.e.: standard error. FDR: false discovery rate.

Adjusted for age, gender, study center, cognitive function, ApoE genotype, and the first ten principal components.

^amean imputation quality score.

^bEffect size in ln(smell score+1) per allele change.