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. 2017 Apr 7;3(5):e152. doi: 10.1097/TXD.0000000000000664

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Copyright © 2017 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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The follow-up years per person was calculated for each of the 5-year periods in our time covariate and plotted against the slopes of the weighted fitted regression lines on the HRs within each period. Although the slope of the latest period, 2009-2013, is least, and might suggest that the effect of HLA matching is becoming less important, this is also the period in which the follow-up time is least, 1.87 years per person. The accuracy of the HRs for HLA matching, as all covariates in a Cox multivariate regression, are sensitive to sample size and follow-up time. Therefore, the stronger effect of HLA, which is apparent in the earlier periods, might very well be present with a higher slope when more data are available.