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Design of mutations within C. glutamicum IlvN. The N-terminal parts of the regulatory subunits of AHAS are shown. Amino acids whose substitution decreased inhibition of AHAS by valine in E. coli (25) or S. cinnamonensis (7) are shaded, and those which are identical in two or all three sequences are in boldface. Amino acids replaced in mutants of C. glutamicum AHAS are boxed. Mutation in E. coli, 14G→D; mutations in S. cinnamonensis, 16G→D, 17V→D, 18L→F, and 30F→L.
