Enrollment and follow-up flow diagram for trial of interventions for opioid dependence. *Miscellaneous reasons (e.g., isolation, sexual assault, deceased). **Miscellaneous reasons (e.g., unable to consent, non-English-speaking, pregnant, deceased, isolation, age < 18, police custody). †The 2-month follow-up occurred during the 10-week treatment period. --- box represents patients transitioned to non-study community treatment per study protocol. MINI Mini International Neuropsychiatric Interview, Referral referral only, Brief Intervention brief intervention and referral, Buprenorphine ED-initiated buprenorphine and referral.