Table 1.
Characteristics of patients. *p < 0.05 versus responder
| All patients (n = 34) | Responder (n = 14) | Non-responder (n = 20) | p value | |
|---|---|---|---|---|
| Age (mean ± SD, years) | 71 ± 14 | 72 ± 14 | 71 ± 15 | 0.89 |
| Gender (male/female, no. of patients) | 21/13 | 7/7 | 14/6 | |
| Patients sources | ||||
| Emergency department | 12 | 5 | 7 | |
| Surgical department | 19 | 8 | 11 | |
| Internal medicine | 3 | 1 | 2 | |
| APACHE II score | 19 ± 7 | 19 ± 5 | 21 ± 7 | 0.53 |
| Type of shock (no. of patients) | ||||
| Septic | 22 | 9 | 13 | |
| Hypovolemic | 10 | 5 | 5 | |
| Obstructive | 1 | 0 | 1 | |
| Cardiogenic | 0 | 0 | 0 | |
| Neurogenic | 1 | 0 | 1 | |
| Duration of shock prior to study inclusion (h) | 13 ± 7 | 12 ± 7 | 14 ± 6 | 0.25 |
| Patients receiving norepinephrine (no. of patients, %) | 22 (65%) | 10 (71%) | 12 (60%) | 0.53 |
| Mechanical ventilation, n (%) | 29 (85%) | 13 (93%) | 16 (80%) | 0.38 |
| Blood gas analysis | ||||
| pH | 7.42 ± 0.07 | 7.45 ± 0.06 | 7.39 ± 0.07 | 0.19 |
| PaO2 (mean ± SD, mmHg) | 159 ± 43 | 159 ± 47 | 159 ± 42 | 0.96 |
| PaCO2 (mean ± SD, mmHg) | 29 ± 5 | 29 ± 6 | 29 ± 5 | 0.86 |
| Hemoglobin (mean ± SD, g/l) | 9.4 ± 1.7 | 9.2 ± 1.7 | 9.5 ± 1.7 | 0.73 |
| FiO2 (%) | 48 ± 7 | 47 ± 5 | 50 ± 8 | 0.23 |
| ScvO2 (mean ± SD, %) | 82 ± 6 | 81 ± 5 | 83 ± 6 | 0.35 |
| Lactate (25–75% interquartile range, mmol/L) | 1.0 (0.7–2.0) | 0.9 (0.7–1.8) | 0.9 (0.7–1.5) | 0.64 |
| PtcO2 (mean ± SD, mmHg) | 106 ± 38 | 92 ± 37 | 114 ± 37 | 0.11 |
| PtcCO2 (mean ± SD, mmHg) | 41 ± 11 | 39 ± 8 | 42 ± 13 | 0.57 |
| ICU stay (25–75% interquartile range, day) | 10 (4–14) | 7 (4–13) | 10 (5–16) | 0.75 |
| In-hospital mortality, n (%) | 15 (44%) | 7 (50%) | 8 (40%) | 0.64 |
SD, standard deviation; APACHE II, acute physiology and chronic health evaluation II; PaO2, arterial oxygen partial pressure; PaCO2, arterial carbon dioxide partial pressure; FiO2, fraction of inspiration oxygen; SaO2, arterial hemoglobin saturation; ScvO2, central venous oxygen saturation; PtcO2, transcutaneous partial pressure of oxygen; PtcCO2, transcutaneous partial pressure of carbon dioxide