Table 2.
Cell lines origin and p53 status
| Cell lines | Cell line description1 | p53 status1 |
| Breast cancer cell lines | ||
| MCF7 | Adenocarcinoma of the mammary gland, derived from 69-year-old female, cells were obtained from metastatic site; pleural effusion | Wild-type[34] |
| 1001 | 1001 is derived from its parental MCF7 (MCF7/R-A1; which are cells exposed to increasing dose of recombinant TNF, transfected by p55 TNF receptor cDNA, Mutation in R280K)[35] | TNF resistant associated with loss of p53 function[35] |
| CAL51 | Adenocarcinoma isolated from a malignant pleural effusion of a 44-year-old female with metastatic breast cancer, normal karyotype with genetic stability[36] | Wild-type[37] |
| ZR-75-1 | Ductal carcinoma of the mammary gland, derived from 63-year-old female, cells were obtained from metastatic site: ascites | Wild-type |
| MDA-MB-361 | Adenocarcinoma of the mammary gland, derived from 40-year-old female, cells were obtained from metastatic site; Brain | Wild-type |
| T47D | ductal carcinoma of the mammary gland, derived from 54-year-old female, cells were obtained from metastatic site; pleural effusion | Heterozygous mutant. |
| MDA-MB-231 | Adenocarcinoma of the mammary gland, derived from 51-year-old female, cells were obtained from metastatic site; pleural effusion. | Homozygous mutant |
| BT549 | Ductal carcinoma of the mammary gland, derived from 72-year-old female, cells were obtained from mammary gland. | Homozygous mutant |
| Colon Cancer Cell lines | ||
| RKO | poorly differentiated colon carcinoma cell line developed by Michael Brattain | Wild-type. |
| RKO-p53 | RKO parental cell line double negative mutant for p53 | Homozygous knock out2 |
| HCT 116 | Colorectal carcinoma of Adult Male derived from primary tumor site | Wild-type |
| HCT 116.p53 | HCT116 parental cell line with hemizygous p53 mutation and knock out of the homologous p53 | R284w/-2 |
| SW480 | Dukes' type B, colorectal adenocarcinoma, derived from 50-year-old male, cells obtained from primary tumor site | Homozygous mutant |
| Positive control for EMT | ||
| HeLa | Cervical adenocarcinoma of 31-year-old female derived from primary tumor site | Wild-Type but HPV inactivated[34] |
1
The cell line origin and the p53 status were from ATCC data sheets/website, the Cancer Cell Line Encyclopedia or the indicated references;
2
As per the source/supplier: Horizon Discovery, Cambridge, United Kingdom.