Table 2.
Diagnostic accuracy of ultrasound measurements of BPD for prenatal assessment of microcephaly.
| Cut-off | −3 SD | −4 SD | −5 SD |
|---|---|---|---|
| Number of cohorts | 218, 19 | 218, 19 | 218, 19 |
| Number of comparisons | 51 | 51 | 51 |
| Diagnostic odds ratio (DOR) | 1.6 (0.056–46.1), I2 = 0% | 4.7 (0.86–25.5), I2 = 0% | 4.7 (0.66–33.9), I2 = 0% |
| AUC | 0.888 | 0.77 | 0.66 |
| Sensitivity | 0.94 (0.67–0.99) | 0.85 (0.46–0.98) | 0.59 (0.30–0.83) |
| Specificity | 0.16 (0.06–0.37) | 0.46 (0.14–0.81) | 0.80 (0.21–0.99) |
| Positive likelihood ratio | 1.1 (0.82–1.5) | 1.6 (0.70–4.5) | 3.0 (0.59–46.0) |
| Negative likelihood ratio | 0.38 (0.047–2.5) | 0.33 (0.045–1.9) | 0.51 (0.21–2.6) |
| PPV (general pregnancy) | 0.00032 | 0.00045 | 0.00084 |
| NPV (general pregnancy) | 0.99989 | 0.99991 | 0.99985 |
| PPV (ZIKV-infected pregnancy) | 0.0106 | 0.0109 | 0.0275 |
| NPV (ZIKV-infected pregnancy) | 0.9964 | 0.9969 | 0.995 |
Parentheses indicate 95% CI. Pre-test probabilities, i.e. incidence of microcephaly among general pregnancies and ZIKV-infected pregnancies were estimated as 0.0285% and 0.95%, respectively.