Table 3.
Diagnostic accuracy of ultrasound measurements of OFD for prenatal assessment of microcephaly.
| Cut-off | −3 SD | −4 SD | −5 SD |
|---|---|---|---|
| Number of cohorts | 218, 19 | 218, 19 | 218, 19 |
| Number of comparisons | 45 | 45 | 45 |
| Diagnostic odds ratio | 18.6 (2.8–124.2), I2 = 0% | 48.0 (4.8–481.5), I2 = 0% | 48.0 (4.8–481.5), I2 = 0% |
| AUC | 0.88 | 0.68 | 0.68 |
| Sensitivity | 0.76 (0.17–0.98) | 0.58 (0.30–0.82) | 0.58 (0.30–0.82) |
| Specificity | 0.84 (0.50–0.97) | 0.97 (0.83–1.00) | 0.97 (0.83–1.00) |
| Positive likelihood ratio | 4.8 (0.73–23.3) | 19.3 (3.0–126.3) | 19.3 (3.0–126.3) |
| Negative likelihood ratio | 0.29 (0.024–1.1) | 0.43 (0.19–0.74) | 0.43 (0.19–0.74) |
| PPV (general pregnancy) | 0.00135 | 0.00548 | 0.00548 |
| NPV (general pregnancy) | 0.99992 | 0.99988 | 0.99988 |
| PPV (ZIKV-infected pregnancy) | 0.0436 | 0.1564 | 0.1564 |
| NPV (ZIKV-infected pregnancy) | 0.9973 | 0. 9959 | 0.9959 |
Parentheses indicate 95% CI. Pre-test probabilities, i.e. incidence of microcephaly among general pregnancies and ZIKV-infected pregnancies were estimated as 0.0285% and 0.95%, respectively.