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. 2017 May 23;7:2283. doi: 10.1038/s41598-017-02276-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of phosphomutants on integration site selection and specificity. (a) Frequency of integration into genes. Stars represent the p-values (***p < 0.001) after comparison of experimental results with matched random control. (b) Heatmap of integration site datasets. For a given integration site dataset, all calculated rank values are averaged. Values between 0 and 0.5: the genomic feature appears less frequently at/near integration sites than at/near random sites in the genome and is disfavored. Values between 0.5 and 1: the genomic feature is enriched at integration sites. Values of exactly 0.5 indicate that integration sites are neither enriched nor depleted with respect to the feature of interest. (c) Frequency of occurrence of each nucleotide at the integration site.